POS1230 OUTCOME FOLLOWING COVID-19 INFECTION IN ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS

Background: Patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) require immunosuppressive therapy for disease control and reduction of relapse may be at risk complications during Sars-CoV-2 (COVID-19) infection. Objectives: To analyze the consequences COVID-19 in a large cohort AAV patients regarding occurrence, need hospitalization, treatment intensive care units (ICU), or death. Methods: Data were retrieved from March 2020 to mid-January 2021 medical records (n=233). diagnosed granulomatosis polyangiitis (GPA), microscopic (MPA) eosinophilic (EGPA) included. included age, gender, diagnosis, ongoing medication onset last follow-up non-COVID individuals. Renal involvement (ever) estimated glomerular filtration rate (eGFR) was confirmed either by positive PCR test upper airways serology. Severe defined as non-invasive ventilation, ICU care, and/or Results: The comprised 172 GPA, 50 MPA 11 EGPA. There 121 females (52%). During study period, 20 (8.6%) COVID-19. median age data retrieval all 68 years (21-93), group 63 (29-93) 68.5 (21-90) patients. Fourty-three (18%) hospitalized period which (4.7%) due In all, 8 deaths occurred 3 related At retrieval, 110 (47%) on prednisolone treatment, 10/20 (50%) 100 non-COVID-19 (p=0.5), significantly higher doses (p<0.001). COVID-19, 6/11 (54.5%) prednisolone, dose 5 mg/day (0-50). total 112 (48%) modifying anti-rheumatic drugs (DMARD) 64 (27.5%) rituximab maintenance therapy. Eight induction cyclophosphamide rituximab. Of cases, had severe these, 2 inactive without 4 stable (5-7.5 mg/day) combination DMARDs, active treated high (25-50 (n=1) (n=1). A proportion (p=0.03) then (10/213 patients). 1/8 (12%) patient therapy, compared 61/213 (28.6%) (p=0.5). present 144 (62%), 6 (30%) COVID- 19, (62%) Median eGFR did not differ between remaining renal independently Conclusion: We found infection our indicates serious complications, especially intense Maintenance seem increase findings stress continued shielding early vaccination Disclosure Interests: None declared